p73: A Multifunctional Protein in Neurobiology

作者：Killick Richard; Niklison Chirou Maria; Tomasini Richard; Bano Daniele; Rufini Alessandro; Grespi Francesca; Velletri Tania; Tucci Paola; Sayan Berna S; Conforti Franco; Gallagher Ewen; Nicotera Pierluigi; Mak Tak W; Melino Gerry; Knight Richard A^*; Agostini Massimiliano

来源：Molecular Neurobiology, 2011, 43(2): 139-146.

DOI：10.1007/s12035-011-8172-6

• p73
• Neuronal differentiation
• Neural stem cells (NSC)
• Neurodegeneration
• Alzheimer's Disease

p73, a transcription factor of the p53 family, plays a key role in many biological processes including neuronal development. Indeed, mice deficient for both TAp73 and Delta Np73 isoforms display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus. TAp73 expression increases in parallel with neuronal differentiation and its ectopic expression induces neurite outgrowth and expression of neuronal markers in neuroblastoma cell lines and neural stem cells, suggesting that it has a pro-differentiation role. In contrast, Delta Np73 shows a survival function in mature cortical neurons as selective Delta Np73 null mice have reduced cortical thickness. Recent evidence has also suggested that p73 isoforms are deregulated in neurodegenerative pathologies such as Alzheimer's disease, with abnormal tau phosphorylation. Thus, in addition to its increasingly accepted contribution to tumorigenesis, the p73 subfamily also plays a role in neuronal development and neurodegeneration.

• 出版日期2011-4