A Versatile Route to (E)- and (Z)-2-Hydroxy-3,4-unsaturated Disubstituted Sultilimines and Their Haloamidation Reaction

作者：Raghavan Sadagopan^*; Mustafa Shaik; Sridhar B

来源：Journal of Organic Chemistry, 2009, 74(12): 4499-4507.

DOI：10.1021/jo900569z

alpha-Chloro ynones have been reduced using Noyori's Ru catalyst to furnish alpha-chloro propargylic alcohols with excellent enantioselectivity. These have been used as a common precursor for the preparation of (E)- and (Z)-2-hydroxy-3,4-unsaturated disubstituted sullfilimines. The latter serve as precursors for the highly regio- and stereoselective preparation of bromo carbamates.

• 出版日期2009-6-19