Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma

作者：Toly Ndour Cecile; Peltier Julie; Piedagnel Remi; Coppo Paul; Sachon Emmanuelle; Ronco Pierre; Rondeau Eric; Callard Patrice; Aucouturier Pierre^*

来源：Nephrology Dialysis Transplantation, 2011, 26(9): 3057-3059.

DOI：10.1093/ndt/gfr377

• acute kidney injury
• crystals
• immunoglobulin light chain
• myeloma

Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi's syndrome with progressive renal insufficiency. We report on a case with severe myeloma featuring lambda light chain-derived crystals and acute kidney injury. Histology showed acute tubular necrosis and tubule obstruction with crystals, which were also abundant inside tubule epithelial cells, macrophages and bone marrow plasma cells. The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals.

• 出版日期2011-9