Ultrasound-radiated synthesis of PAMAM-Au nanocomposites and its application on glucose biosensor

作者：Wei, Yinyin; Li, Ying; Zhang, Ningdan; Shi, Guoyue; Jin, Litong^*

来源：Ultrasonics Sonochemistry, 2010, 17(1): 17-20.

DOI：10.1016/j.ultsonch.2009.06.017

• PAMAM-Au
• Ultrasound irradiation
• Glucose oxidase
• Glucose biosensor

Hybrid nanocomposites of carboxyl-terminated generation 4 (G 4) poly(amidoamine) dendrimers (PAMAM) with gold nanoparticles (AuNPs) encapsulated inside them were synthesized under ultrasound irradiation, The obtained nanocomposites were used to fabricate highly sensitive amperometric glucose biosensor which exhibited a high and reproducible sensitivity of 2.9 mA/mM/cm(2), response time less than 5 s, linear dynamic range from 0.1 to 15.8 mu M, correlation coefficient of R-2 = 0.9988, and limit of detection (LOD), based on S/N ratio (S/N = 3) of 0.05 mu M. A value of 2.7 mM for the apparent Michaelis-Menten constant K-M(app) was obtained. The high sensitivity, wider linear range, good reproducibility and stability make this biosensor a promising candidate for portable amperometric glucose biosensor.

• 出版日期2010-1
• 单位华东师范大学