Association between rs6887695 and 3 '-untranslated region polymorphisms within the interleukin-12B gene and susceptibility to autoimmune diseases in Asian and European population: A meta-analysis

作者：Xiao, Jian-Ping; Wang, Xue-Rong; Zhang, Sen; Wang, Hai-Yan; Ye, Lei; Pan, Hai-Feng; Wang, De-Guang^*

来源：Autoimmunity, 2016, 49(4): 277-284.

DOI：10.3109/08916934.2016.1166215

• Autoimmune disease (AD)
• IL-12B rs6887695
• IL-12B 3 '-untranslated region
• meta-analysis
• polymorphism

Background: The associations between rs6887695 and 3'-untranslated region (3'-UTR) single-nucleotide polymorphisms (SNPs) within interleukin-12B (IL-12B) and autoimmune diseases (ADs) remain controversial and inconclusive. The aim of this study was to evaluate the association between IL-12B (3'-UTR A/C and rs6887695 C/G SNPs) and ADs by meta-analysis. Methods: PubMed and EMBASE were exhaustively searched for studies on the association between IL-12B SNPs and ADs. Publication bias was examined by a funnel plot and Egger's test. The robustness of the pooled results was assessed by sensitivity analysis. A fixed-or a random-effects model was applied to calculate the pooled odds ratios (ORs). Results: A total of 34 studies were included in this meta-analysis. The pooled results demonstrated that IL-12B rs6887695 SNPs were significantly associated with the risk of ADs. However, there was no significant association between IL-12B 3'-UTR SNPs and ADs. When the studies were stratified by ethnicity, significant association between IL-12B 3'-UTR SNPs and ADs was observed in both Asian and European population. In addition, allele A within 3'-UTR of IL-12B gene was found to be a protective factor for T1DM, but a risk factor for psoriasis. Conclusion: The IL-12B 3'-UTR and rs6887695 SNPs are associated with susceptibility to ADs.

• 出版日期2016
• 单位安徽医科大学