Asymmetric sequential double Michael reactions of gamma,delta-unsaturated beta-ketoesters to nitroolefins catalyzed by Ni (II)-diamine complex

作者：Huang Shengying; Scherer Karen; Ni Bukuo^*

来源：Catalysis Communications, 2017, 102: 67-70.

DOI：10.1016/j.catcom.2017.08.024

• Asymmetric catalysis
• Michael reaction
• Nickel (II) complex
• Nitroolefins
• beta-ketoesters
• Cyclohexenol derivatives

The asymmetric sequential double Michael reactions of gamma,delta-unsaturated beta-ketoesters and nitroolefins catalyzed by 2 mol% of readily prepared Ni(II)-bis[(R,R)-N,N'-dibenzylcyclohexane-1,2-diamine] complex and then with 1 equivalent of tetramethylguanidine (TMG) for cyclization have been developed. The reaction gave the corresponding Michael adducts of multifunctional cyclohexenol derivatives with three chiral stereocenters in good yields, moderate diastereoselectivities, and high enantioselectivities under mild reaction conditions.

• 出版日期2017-12