A novel and environmental friendly, one-step synthesis of 2,6-Diamino-4-phenyl pyrimidine-5-carbonitrile using potassium carbonate in water

作者：Deshmukh M B^*; Anbhule P V; Jadhav S D; Jagtap S S; Patil D R; Salunkhe S M; Sankpal S A

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2008, 47(5): 792-795.

• green synthesis
• pyrimidine
• phase transfer catalyst
• Potassium carbonate

A green, simple and environmentally friendly approach has been carried out towards one-step synthesis of 2,6-diamino-4-phenyl pyrimidine-5-carbonitrile by three-component condensation of aromatic aldehydes, malononitrile and guanidine hydrochloride in aqueous medium using potassium carbonate and in the presence of tetrabutyl ammonium bromide.

• 出版日期2008-5