Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

作者：Randall Ken; Stevens Jason; Yepes Juan Fernando; Randall Marcus E; Kudrimoti Mahesh; Feddock Jonathan; Xi Jing; Kryscio Richard J; Miller Craig S^*

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2013, 115(6): 772-779.

DOI：10.1016/j.oooo.2013.01.006

Objectives. Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. %26lt;br%26gt;Methods. A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. %26lt;br%26gt;Results. HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P %26gt; .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P %26lt; .04) and linear mixed models (P %26lt; .0001). %26lt;br%26gt;Conclusions. Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

• 出版日期2013-6