Oral administration versus iontophoresis of Sang-Su decoction (a formula for dispersing lung to calm panting and resolve phlegm and for dredging collateral) in the treatment of acute bronchial asthma: a comparative study on their efficacy and impacts on the prognosis

作者：Su, Yinghao; Yu, Xiangyan; Geng, Limei; Su, Kuiguo; Guo, Yongying; Yannageng; Ma, Yunlei^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(2): 1305-1311.

• Asthma
• Sang-Su decoction
• traditional Chinese medicine iontophoresis

Objective: To investigate the efficacy of oral administration versus traditional Chinese medicine (TCM) iontophoresis of Sang-Su decoction (SSD) in the treatment of acute bronchial asthma (ABA) and their impacts on the clinical prognosis. Methods: One hundred patients with ABA were randomly and equally divided into two groups: A and B. In group A, patients were given the oral administration of SSD, a self-made formula for dispersing lung to calm panting and resolve phlegm as well as dredging collateral (mulberry leaf 10 g, perilla leaf 10 g, pericarpium citri reticulatae 10 g, rhizoma pinelliae 10 g, tuckahoe 10 g, radix glycyrrhizae preparata 6 g, thunberg fritillary bulb 10 g, bombyx batryticatus 10 g, trichosanthes kirilowii maxim 15 g, herba schizonepetae 10 g, houttuynia cordata thunb 15 g, scutellaria baicalensis 10 g), while in group B, patients received TCM iontophoresis of SSD. After 4 weeks of treatment (4 weeks), the comprehensive therapeutic efficacy in both groups was assessed (rate of reduction in TCM syndrome score). Meanwhile, the following variables before and after treatment were evaluated and compared in two groups: scores of asthma control test (ACT), pulmonary forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) 25%-75%, both of which were expressed as a percentage of their predicted values), eosinophil (EOS) counts in the peripheral blood, and serum immunoglobulin E (IgE) levels. The frequency of acute asthma attacks within half a year after the treatment was also compared between two groups. Results: After treatment, significant clinical effects of the TCM therapy were observed in both groups, however, the efficacy in group B was even greater (P<0.05). The ACT scores in both groups rose significantly after treatment, while the score in group B was higher than that in group A (P<0.05). The value of FEVI and PEF 25%-75% were improved similarly in two groups (P>0.05). EOS counts in the peripheral blood and serum IgE levels all decreased after treatment, and the decreases in group B were greater (both P<0.05). There was no intergroup difference in the frequency of attacks within half a year after treatment (both P>0.05). Conclusion: In comparison with the treatment method using SSD only, the method using the combination of SSD and TCM iontophoresis can achieve more significant efficacy in treating ABA without improvement on the prognosis.

• 出版日期2018
• 单位河北省人民医院