Neurologic relapse in dogs with lymphosarcoma treated with chemotherapy: a review of 13 cases

作者：Martinez de Merlo E M; Portero M; Costo J M; Arconada L

来源：Clinica Veterinaria de Pequenos Animales, 2011, 31(4): 217-224.

• Cancer
• canine
• rescue therapy
• brachycephalic breeds
• cerebrospinal fluid

A retrospective study of 13 cases of dogs treated with chemotherapy for lymphosarcoma that suffered relapse with central or peripheral nervous system involvement was performed in order to describe findings and response to treatment. No statistical correlation was found between sex, age, clinical stage or presentation of neoplastic disease with the onset of neurological signs. However, the study indicates a racial predisposition to suffer neurologic relapse in pure breed dogs, and an increased risk in brachycephalic breed. Neuroanatomical location was mainly intracranial (7 cases) whereas spinal cord involvement (3 cases) and multifocal location (3 cases) occur less commonly. The most common presenting neurological signs were seizures, abnormal behavior and hind limb weakness, followed by thoracolumbar pain and bilateral trigeminal nerve paralysis. Cerebrospinal fluid analysis was performed in 6 patients; all of them were diagnosed of secondary involvement lymphoma. Some cases were treated with specific therapheutic agents for neurologic symptoms and all of them had an excellent initial response; despite this fact, long-lasting control of symptoms is not achieved, with an average remission time of 50 days.

• 出版日期2011