Associations of Four Community Factors With Longitudinal Change in Hemoglobin A(1c) Levels in Patients With Type 2 Diabetes

作者：Hirsch Annemarie G.^*; Durden T. Elizabeth; Nordberg Cara; Berger Andrea; Schwartz Brian S.

来源：Diabetes Care, 2018, 41(3): 461-468.

DOI：10.2337/dc17-1200

OBJECTIVE
To evaluate associations of community factors with glycated hemoglobin (HbA(1c)).
RESEARCH DESIGN AND METHODS
We identified patients with type 2 diabetes who had an HbA(1c) >= 7.5% (58 mmol/mol) and subsequent HbA(1c) testing within 90-270 days. We used mixed-effect models to assess whether treatment intensification (TI) and community domains (community socioeconomic deprivation [CSD], food availability, fitness assets, and utilitarian physical activity favorability [quartiled]) were associated with HbA(1c) change over 6 and 24 months, controlling for demographics, HbA(1c), BMI, and time with evidence of type 2 diabetes. We evaluated whether community domains modified associations of TI with HbA(1c) change using cross product terms.
RESULTS
There were 15,308 patients with 69,818 elevated HbA(1c) measures. The average reduction in HbA(1c) over 6 months was 0.07% less in townships with a high level of CSD (third quartile versus the first). Reductions were 0.10% greater for HbA(1)c in townships with the best food availability (versus worst). HbA(1c) reductions were 0.17-0.19% greater in census tracts in the second and third quartiles of utilitarian physical activity favorability versus the first. The association of TI with 6-month HbA(1c) change was weaker in townships and boroughs with the worst CSD (versus best) and in boroughs with the best fitness assets (versus worst). The association of TI with 24-month HbA(1c) change was weaker in census tracts with the worst CSD (versus third quartile) and strongest incensus tracts most favorable for utilitarian physical activity (versus worst).
CONCLUSIONS
Community domains were associated with HbA(1c) change and blunted TI effectiveness.

• 出版日期2018-3