Double diastereoselective SuperQuat glycolate aldol reactions: Application to the asymmetric synthesis of polyfunctionalised lactones

作者：Davies SG^*; Nicholson RL; Smith AD

来源：Organic and Biomolecular Chemistry, 2004, 2(22): 3385-3400.

DOI：10.1039/b411724g

Polyfunctionalised lactones with up to five contiguous stereocentres may be prepared with high stereocontrol by a double diastereoselective aldol protocol with protected homochiral alpha, beta-dihydroxy- or alpha, beta-gamma-trihydroxyaldehydes and a chiral glycolate oxazolidinone, followed by subsequent O-desilylation and lactonisation.

• 出版日期2004