Updated Reference Ranges for the Ductus Venosus Pulsatility Index at 11-13 Weeks

作者：Sabria Joan^*; Comas Carmina; Barcelo Vidal Carles; Garcia Posada Raul; Echevarria Monica; Dolors Gomez Roig Maria; Borrell Antoni

来源：Fetal Diagnosis and Therapy, 2012, 32(4): 271-276.

DOI：10.1159/000339413

• Ductus venosus
• Prenatal screening
• Trisomy 21
• Down syndrome
• Ultrasound markers

Objective: To update the reference ranges for the ductus venosus pulsatility index (DVPI) at 11+0 to 13+6 gestational weeks. Methods: DVPI was calculated in 14,444 singleton fetuses at 11+0 to 13+6 weeks in two Fetal Medicine Centers, during a 4-year period. Using previously described medians, DVPI evolution was assessed both over the study period on a yearly basis and over gestation, grouping fetuses according to 5-mm crown-rump length (CRL) ranges. Weighted DVPI medians, the 5th and 95th percentiles and distribution parameters for unaffected and trisomy 21 fetuses were newly calculated. Results: A significant DVPI multiple of the median decrease was observed over both the study period (p %26lt; 0.01) and over gestation (p %26lt; 0.01) using previous medians, in the two centers. Newly calculated weighted medians were lower than those previously described, decreasing with CRL. Distribution parameters calculated using the new medians were different from those previously described. Conclusion: DVPI reference ranges were lower than those previously reported and decreased with CRL. Updated medians and distribution parameters should be considered to include the DVPI as a Gaussian marker in trisomy 21 screening and for quality control purposes.

• 出版日期2012