A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J mice

作者：Lu, Jing; Wang, Zhenning; Ren, Mengrou; Feng, Guangxin; Ye, Beining; Wang, Yi; Fang, Baochen; Deng, Xuming; Guan, Shuang^*

来源：Environmental Toxicology and Pharmacology, 2015, 40(2): 453-458.

DOI：10.1016/j.etap.2015.07.017

• 3-MCPD diesters
• Hyperlipidemia
• C57BL/6J mice
• In vivo

3-Monochloropropane-1,2-diol (3-MCPD) esters have been detected in many foods, which have become a new safety issue worldwide. In the study, we investigated the effect of four 3-MCPD diesters (palmitate diester: CDP; stearate diester: CDS; oleate diester: COO; linoleate diester: CDL) on lipid metabolism in C57BL/6J mice. The results showed that COP, CDS, COO and CDL significantly increased the serum TC, LDL-C levels and liver TG, TC levels at dose of 16.5 mu mol/kg/clay. These results indicated that 3-MCPD diesters could potentially cause hyperlipidemia in C57BL/6J mice. Moreover, oil red 0 staining confirmed fat accumulation in liver induced by 3-MCPD diesters. Our work will provide more information for safety evaluation of 3-MCPD diesters. However, whether free 3-MCPD or free fatty acids or combined action compensates for the hyperlipidemia effects should be elucidated in the future.

• 出版日期2015-9
• 单位吉林大学