NUCLEOTIDES PART LXXX: SYNTHESIS OF 3 '-O FLUORESCENCE LABELED THYMIDINE DERIVATIVES AND THEIR 5 '-O-TRIPHOSPHATES

作者：Prykota Tamara I; Pfleiderer Wolfgang^*

来源：Nucleosides Nucleotides & Nucleic Acids, 2011, 30(7-9): 544-551.

DOI：10.1080/15257770.2011.578089

• Isoxanthopterin derivatives
• fluorescent marker
• thymidine conjugates
• nucleoside 5 '-triphosphates

A new labeling technique attaching a fluorescent pteridine derivative (3, 5) via a linker onto the 3'-OH group of 5'-O-dimethoxytritylthymidine (7) was developed to lead to the conjugates 8 and 11. After detritylation to give 9 and 12, the final conversion into the corresponding 5'-triphosphates (13, 14), which were isolated as sodium salts, was performed by known methods.

• 出版日期2011-9