alpha(1)-Adrenergic Receptors Contribute to the Acute Effects of 3,4-Methylenedioxymethamphetamine in Humans

作者：Hysek Cedric M; Fink Anja E; Simmler Linda D; Donzelli Massimiliano; Grouzmann Eric; Liechti Matthias E^*

来源：Journal of Clinical Psychopharmacology, 2013, 33(5): 658-666.

DOI：10.1097/JCP.0b013e3182979d32

• MDMA
• 3,4-methylenedioxymethamphetamine
• norepinephrine
• doxazosin
• alpha(1)-adrenergic receptor

Preclinical studies implicate a role for alpha(1)-noradrenergic receptors in the effects of psychostimulants, including 3,4-methylenedioxymethamphetamine (MDMA, %26quot;ecstasy%26apos;%26apos;). The present study evaluated the effects of the alpha(1)-noradrenergic receptor antagonist doxazosin on the acute pharmacodynamic and pharmacokinetic response toMDMA in 16 healthy subjects. Doxazosin (8 mg/d) or placebo was administered for 3 days before MDMA (125 mg) or placebo using a randomized, double-blind, placebo-controlled, 4-session, crossover design. Doxazosin reduced MDMA-induced elevations in blood pressure, body temperature, and moderately attenuated positive mood but enhanced tachycardia associated with MDMA. The results indicate that alpha(1)-adrenergic receptors contribute to the acute cardiostimulant and to a minor extent possibly also to the thermogenic and euphoric effects of MDMA in humans.

• 出版日期2013-10