科研之友
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摘要
Reverse transeriptase enzyme (RT) is an attractive target for the development of new drugs useful in AIDS therapy and HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs), and offers the possibility of generating structures of increased potency. On this basis, a series of 4-oxo-3-pheny1-2-(phenylimino)thiazolidin-5-ylidene, 3-hydroxypropyl, 3-azidopropyl, and 3-aminopropyl derivatives of 1-benzyl-2-ethyl-4-nitroimidazoles 6-8, as well as the substituted 1,2,3-triazolo analogs 12-14, the diazepam 15 and earboxamide derivatives 16 and 17 were synthesized. All compounds have been evaluated for their anti-HIV activity.
- 出版日期2012-8
- 单位河北医科大学
