Anticholinergic effect on cognition (AEC) of drugs commonly used in older people

作者：Bishara Delia; Harwood Daniel; Sauer Justin; Taylor David M^*

来源：International Journal of Geriatric Psychiatry, 2017, 32(6): 650-656.

DOI：10.1002/gps.4507

• dementia
• cognitive function
• anticholinergic

Objective: Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death.
Method: We identified drugs widely used in older people and attempted to classify their anticholinergic effect on cognition (AEC) according to our three-point scale which scored AEC according to in vitro anticholinergic potency, capacity to cross the blood-brain barrier and statements made in standard texts.
Results: In total, 165 drugs were examined. We identified 21 drugs with an AEC score of 3, 18 with a score of 2, 21 with a score of 1 and 62 with a score of 0. Owing to insufficient information, we were unable to classify 43 drugs.
Conclusions: A large number of drugs commonly used in older people are likely to be associated with cognitive impairment.

• 出版日期2017-6