摘要

PVP/Pd/IrO2/Nafion microsensor was fabricated to measure nitric oxide production in fibrocytes directly. In the experiments, fibrocytes did not release nitric oxide after stimulated with L-arginine and acetylcholine under normal condition. After induced with hpopolysaccharide, NO was produced in high concentration and NO levels were increased after stimulated with L-arginine and acetylcholine. On the other hand, L-N-w-nitro-arginine, an NO synthase inhibitor, decreased the action of L-arginine and acetylcholine.