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摘要
The Suzuki-Miyaura reaction of 4-amino-3,5-dibromo-2,6-lutidine with various ortho-substituted phenylboronic acids resulted in the formation of a series of mono-and diarylated lutidines in the form of atropisomers. The absolute stereochemistry of the chiral compounds was established, in some cases, by X-ray crystal structure analysis and HPLC-ECD (ECD = electronic circular dichroism) in combination with time-dependent density functional theory (TDDFT) calculations.
- 出版日期2016-6
