Accuracy of multidetector-row CT for restaging after neoadjuvant treatment in patients with oesophageal cancer

作者：Konieczny Agnieszka; Meyer Philipp; Schnider Annelies; Komminoth Paul; Schmid Mathias; Lombriser Norbert; Weishaupt Dominik^*

来源：European Radiology, 2013, 23(9): 2492-2502.

DOI：10.1007/s00330-013-2844-8

• Oesophageal cancer
• Multidetector-row computed tomography
• Neoadjuvant treatment
• Tumour staging
• Multislice computed tomography

To assess the diagnostic accuracy of 64-multidetector CT (MDCT) for restaging of patients with oesophageal cancer undergoing neoadjuvant therapy.
Results of pathological staging were correlated with those from 64-MDCT before and after neoadjuvant treatment in 35 patients using the American Joint Committee on Cancer/TNM classification (7th edition). CT response was determined using the Response Evaluation Criteria in Solid Tumours (RECIST) method, modified for one-dimensional tumour diameter measurement.
64-MDCT predicted T stage correctly in 34 % (12/35), overstaged in 49 % (17/35) and understaged in 17 % (6/35). Sensitivity/specificity values were as follows: T0, 20 %/92 %; T1-T2, 31 %/59 %; T3, 60 %/64 %; T4, 100 %/4 %. Negative predictive values for T3/T4 were 80 %/100 %. MDCT accurately predicted complete histopathological response in 20 % (accuracy 74 %) and overstaged in 80 %. Tumour regression grade was predicted correctly in only 8 % (2/25) and underestimated in 68 % (17/25). Accurate N stage was noted in 69 % (24/35).
Although MDCT tends to be able to exclude advanced tumour stages (T3, T4) with a higher likelihood, the diagnostic accuracy of high resolution MDCT for restaging oesophageal cancer and assessing the response to neoadjuvant therapy has not improved in comparison to older-generation CT. Therefore, the future assessment of oesophageal tumour response should focus on combined morphologic and metabolic imaging.
Multidetector CT (MDCT) has been beneficial for the evaluation of many tumours.
However diagnostic accuracy for restaging oesophageal cancer has not improved with MDCT.
MDCT tends to be able to exclude advanced tumour stages (T3/T4).
MDCT has a low accuracy for determining lymph node metastasis.
Oesophageal tumour response should be assessed by combined morphological and metabolic imaging.

• 出版日期2013-9