The use of subcutaneous glycopyrrolate in the management of sialorrhoea and facilitating the use of non-invasive ventilation in amyotrophic lateral sclerosis

作者：Cooper Knock Johnathan^*; Ahmedzai Sam H; Shaw Pamela

来源：Amyotrophic Lateral Sclerosis, 2011, 12(6): 464-465.

DOI：10.3109/17482968.2011.584195

• Glycopyrrolate
• sialorrhoea
• amyotrophic lateral sclerosis
• non-invasive ventilation

Sialorrhoea is a recognized complication of bulbar amyotrophic lateral sclerosis (ALS) that leads to an increased risk of potentially harmful aspiration and often prevents patients from tolerating non-invasive ventilation (NIV). A case of treatment-resistant sialorrhoea in bulbar ALS is described where subcutaneous glycopyrrolate was effective without significant side-effects. The patient went on to markedly increase the length of time she could tolerate NIV each night.

• 出版日期2011-11