Ammonia Plasma Functionalized Polycarbonate Surfaces Improve Cell Migration Inside an Artificial 3D Cell Culture Module

作者：Bergemann Claudia^*; Quade Antje; Kunz Friederike; Ofe Stefan; Klinkenberg Ernst Dieter; Laue Michael; Schroeder Karsten; Weissmann Volker; Hansmann Harald; Weltmann Klaus Dieter; Nebe Barbara

来源：Plasma Processes and Polymers, 2012, 9(3): 261-272.

DOI：10.1002/ppap.201100059

• ammonia plasma
• cell adhesion
• human osteoblasts
• polycarbonate
• surface modification

A three-dimensional (3D) cell culture module was used to test the requirements of scaffold material properties for improved bone cell ingrowth. For this purpose polycarbonate (PC) samples were treated with microwave-excited ammonia plasma in a defined time frame of 1300?s and the influence on initial attachment of osteoblast-like cells was determined. Perforated PC slices were treated by 30?s of ammonia plasma and mounted on a clamp for 3D cell ingrowth. Plasma treatment conditions were ascertained to stimulate cell adhesion and the migration of human bone cells into the depth of this artificial scaffold.

• 出版日期2012-3