A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum

作者：Joseph Soniamol; Janardhanan Kainoor K; George Varughese; Baby Sabulal^*

来源：Phytochemistry Letters, 2011, 4(3): 386-388.

DOI：10.1016/j.phytol.2011.08.011

• Ganoderma lucidum
• Lanostane-type triterpenoids
• 8 alpha,9 alpha-Epoxy-3,7,11,15,23-pentaoxo-5 alpha-lanosta-26-oic acid

A new epoxidic ganoderic acid, 8 alpha,9 alpha-epoxy-3,7,11,15,23-pentaoxo-5 alpha-lanosta-26-oic acid (1), together with the known compounds 3 beta-hydroxy-7,11,15,23-tetraoxo-5 alpha-lanosta-8-en-26-oic acid (2), ergosta-7,22-diene-3 beta-yl pentadecanoate (3), ergosta-7,22-diene-3 beta-ol (4), beta-sitosterol (5), fatty acids (6-10), fatty acid ester (11) and octadecane (12) were isolated from the fruiting bodies of Ganoderma lucidum from south India. Their structures were determined by (1)H, (13)C, (13)C DEPT, (1)H-(1)H COSY, HMBC, HSQC, NOESY NMR, FT-IR, UV-vis and FABMS spectral analysis. Compounds (1-3) exhibited good antifungal activity against Candida albicans in disc diffusion assay (100 mu g/disc). Steroid ester (3) showed moderate anti-inflammatory activity (59.7% inhibition, 100 mg/kg body weight) in carrageenan-induced paw edema.

• 出版日期2011-9