Detrimental effects of hyperandrogenism on uterine functions

作者：Elia Evelin; Vighi Susana; Lombardi Eduardo; Motta Alicia Beatriz^*

来源：International Immunopharmacology, 2008, 8(13-14): 1827-1834.

DOI：10.1016/j.intimp.2008.09.002

• Polycystic ovary syndrome
• Dehydroepiandrosterone
• Uterus
• T lymphocytes
• Prostaglandins
• Reactive oxygen species
• Catalase
• Superoxide dismutase
• Glutathione

The aim of the present work was to study some of the adverse effects produced by hyperandrogenism on the uterine function. Daily injection of dehydroepiandrosterome (DHEA: 6 mg/ 100 g body weight, sc) for 20 consecutive days induced polycystic ovaries in BALB/c mice. In this model, we found that DHEA produced alterations on uterine histology closely related to the development of turnout structures. In addition, hyperandrogenism induced a pro-inflammatory and a pro-oxidant condition represented by increased levels of prostaglandin F2 alpha production and uterine nitric oxide synthase (NOS) activity and by a decrease in both superoxide dismutase (SOD) and catalase (CAT) activities together with a decrease in the levels of the antioxidant metabolite glutathione (GSH). DHEA also induced an increase in CD4+ together with a decrease in the CD8+ T lymphocytes that infiltrate the uterine tissue. We conclude that this intricate network of regulators could be responsible for the low rate of implantation observed in women with polycystic ovary syndrome.

• 出版日期2008-12-20