Association between hsa-mir-149C %26gt; T (rs2292832) and susceptibility to hepatocellular carcinoma: a meta-analysis

作者：Zheng Yuanyuan; Li Jingjing; Dai Weiqi; Zhang Rong; Wang Jianrong; Lu Wenxia; Zhou Yuqing; Yin Qin; Abudumijiti Huerxidan; Chen Rongxia; Chen Kan; Li Sainan; Liu Tong; Wang Fan; Xia Yujing; Lu Jie; Zhou Yingqun; Guo Chuanyong

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(9): 17040-17049.

• Hepatocellular carcinoma
• hsa-mir-149C &gt
• T
• rs2292832
• miRNA polymorphism
• meta-analysis

miRNAs are a family of small non-coding RNAs that participate in diverse biological processes and play an important role in tumor progression. Single nucleotide polymorphisms miRNA genes may influence the expression and biological function of some miRNAs. In this meta-analysis, we calculated the odds ratio (OR) and 95% confidence interval (CI) for rs2292832 and its correlation with the risk of hepatocellular carcinoma (HCC) based on 1700 cases and 2044 controls. Our results suggest that rs2292832is associated with the risk of HCC, TT/CT may play a conservative role in disease progression (T vs. C: OR= 0.91, 95% CI=0.74-1.13, P=0.400, p(h)=0.008; TT/CT vs. CC: OR=0.80, 95% CI=0.67-0.95, P=0.013, p(h)=0.286; TT vs. CT/CC: OR=0.94, 95% CI=0.70-1.26, P=0.672, p(h)=0.018; TT vs. CC: OR=0.77, 95% CI=0.62-0.95, P=0.014, p(h)=0.068; CT vs. CC: OR=0.82, 95% CI=0.68-0.99, P=0.035, p(h)=0.799; CT vs. CC/TT: OR=0.94, 95% CI=0.82-1.07, P=0.330, p(h)=0.533).

• 出版日期2016
• 单位苏州大学; 宿州学院; 同济大学; 南京医科大学