Novel amphiphilic ternary polysaccharide derivates chitosan-g-PCL-b-MPEG: Synthesis, characterization, and aggregation in aqueous solution

作者：Lu, Yiye; Liu, Li; Guo, Shengrong^*

来源：Biopolymers, 2007, 86(5-6): 403-408.

DOI：10.1002/bip.20743

• chitosan
• polycaprolactone
• poly(ethylene glycol)
• graft copolymer

Chitosan-g-PCL-b-MPEG copolymers of various compositions were successful synthesized via a protection-graft-deprotection procedure, by the esterification of phthaloyl-protected chitosan (PHCS) with MPEG-b-PCL-COOH, which was synthesized from MPEG and epsilon-caprolactone and carboxylated by maleic anhydride. The chemical structure of the chitosan-g-PCL-b-MPEG was characterized by Fourier transform infrared and NMR spectroscopy. The chitosan-g-PCL-b-MPEG was obtained as amphoteric hybrid with amino polysaccharide backbone and amphiphilic MPEG-b-PCL side chain. Their crystallinity and aggregation behavior in aqueous solution were also investigated.

• 出版日期2007-8-5
• 单位上海交通大学