摘要

An efficient and practical method has been developed for the facile synthesis of 1,2,4-trioxanes by the condensation of beta-hydroperoxy alcohols and carbonyl compounds in the presence of a catalytic amount of silica-supported ferric chloride (FeCl3/SiO2) at room temperature. The method has the benefits of operational simplicity, high yields and potential large-scale application. Moreover, the catalyst can be readily recovered by simple filtration and reused up to five times while almost maintaining its catalytic activity.