First Example of C-3 Alkylation of Indoles with Activated Azetidines Catalyzed by Indium(III) Bromide

作者：Yadav J S^*; Reddy B V Subba; Narasimhulu G; Satheesh G

来源：Synlett, 2009, 2009(5): 727-730.

DOI：10.1055/s-0028-1087957

• indoles
• indium(III) bromide
• activated azetidine
• C-3 alkylation

Indoles undergo smooth alkylation with N-tosylazetidines in the presence of indium(III) bromide in dichloroethane under mild conditions to produce the corresponding C-3 Substituted indole derivatives in good to high yields and with high selectivity. This is the first report oil the alkylation of indoles with activated azetidines.

• 出版日期2009-3-17