Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit

作者：Hoo Guy W Soo^*; Lin Henry K; Junaid Imran; Klaustermeyer William B

来源：American Journal of Medicine, 2015, 128(7): 785-789.

DOI：10.1016/j.amjmed.2015.02.006

• Angioedema
• Angiotensin-converting enzyme inhibitor
• Respiratory failure

OBJECTIVE: The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit.
METHODS: Fifty subjects with ACE-inhibitor angioedema admitted from 1998-2011 were reviewed.
RESULTS: All 50 subjects were men, 62.8 +/- 8.4 years of age, 76% African Americans. Fifteen (30%) required ventilatory support and 2 (4%) required tracheostomy. Over half (56%) had taken ACE inhibitors for over a year. Logistic regression identified dyspnea and tongue involvement with the need for ventilatory support (P < .01). Hypercapnia (PaCO2 +/- 45.2 +/- 6.7; P < 0.046) also identified patients needing ventilatory support.
CONCLUSIONS: Ventilatory support was provided for about one-third of those with ACE inhibitorassociated angioedema. Angioedema can occur even after extended use. Dyspnea and tongue involvement identified patients requiring ventilatory support. Published by Elsevier Inc.

• 出版日期2015-7