Assembly of Spirooxindole Derivatives via Organocatalytic Iminium-Enamine Cascade Reactions

作者:Albertshofer Klaus; Anderson Kimberly E; Barbas Carlos F III*
来源:Organic Letters, 2012, 14(23): 5968-5971.
DOI:10.1021/ol302876c

摘要

The assembly of complex spirocyclopentaneoxindoles via a novel organocatalytic iminium-enamine cascade process is reported. Reactions between 3-substituted oxindoles and alpha,beta-unsaturated aldehydes catalyzed by second generation prolinol ethers provided the desired products in high yield with excellent levels of enantioselectivity in a single step.

  • 出版日期2012-12-7