Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles

作者：Wipf Peter^*; Manojlovic Marija D

来源：Beilstein Journal of Organic Chemistry, 2011, 7: 824-830.

DOI：10.3762/bjoc.7.94

• allene
• 3-aminotetrahydrofurans
• 3-and 4-aminotetrahydropyrans
• hydrozirconation
• nitrile
• transmetalation

The one-pot hydrozirconation of allenes and nitriles followed by an in situ transmetalation of the allylzirconocene with dimethylzinc or zinc chloride provides functionalized homoallylic amines. An intramolecular version of this process leads to 3-aminotetrahydrofurans and 3-aminotetrahydropyrans.

• 出版日期2011-6-17