Convenient way of synthesis and crystal structure of 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, a histamine H-4 receptor antagonist

作者：Lazewska Dorota; Karolak Wojciechowska Janina; Kolesinska Beata; Kaminski Zbigniew; Kiec Kononowicz Katarzyna^*

来源：Heterocyclic Communications, 2011, 17(5-6): 207-210.

DOI：10.1515/HC.2011.035

• 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine (JNJ 7777120)
• 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate
• amide formation
• crystal structure
• histamine H-4 antagonist

1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine (JNJ 7777120) is the known histamine H-4 receptor reference compound. The convenient way of its synthesis and the crystal structure are described.

• 出版日期2011-12