Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China

作者：Lu, Shao-you; Li, Yan-xi; Zhang, Jian-qing; Zhang, Tao^*; Liu, Gui-hua; Huang, Ming-zhi; Li, Xiao; Ruan, Ju-jun; Kannan, Kurunthachalam; Qiu, Rong-liang^*

来源：Environment International, 2016, 94: 161-169.

DOI：10.1016/j.envint.2016.05.021

• E-waste recycling
• Polycyclic aromatic hydrocarbons
• Oxidative stress
• 8-hydroxy-2 '-deoxyguanosine
• Malondialdehyde

Emission of polycyclic aromatic hydrocarbons (PAHs) from e-waste recycling activities in China is known. However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China. The urinary levels of Sigma 10OH-PAHs determined in e-waste recycling area (GM: 25.4 mu g/g Cre) were significantly higher (p < 0.05) than those found in both rural (11.7 mu g/g Cre) and urban (10.9 mu g/g Cre) reference areas. The occupationally exposed e-waste workers (36.6 mu g/g Cre) showed significantly higher (p < 0.01) urinary Sigma 10OH-PAHs concentrations than non-occupationally exposed people (23.2 mu g/g Cre) living in the e-waste recycling site. The differences in urinary Sigma 10OH-PAHs levels between smokers (23.4 mu g/g Cre) and non-smokers (24.7 mu g/g Cre) were not significant (p > 0.05) in e-waste dismantling sites, while these differences were significant (p < 0.05) in rural and urban reference areas; this indicated that smoking is not associated with elevated levels of PAH exposure in e-waste dismantling site. Furthermore, we found that urinary concentrations of Sigma 10OH-PAHs and individual OH-PAHs were significantly associated with elevated 8-OHdG, in samples collected from e-waste dismantling site; the levels of urinary 1-hydroxypyrene (1-PYR) (r = 0.284, p < 0.01) was significantly positively associated with MDA. Our results indicate that the exposure to PAHs at the e-waste dismantling site may have an effect on oxidative damage to DNA among selected participants, but this needs to be validated in large studies.

• 出版日期2016-9
• 单位深圳市疾病预防控制中心; 中山大学