Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein

作者：Andreasson, Hakan; Wanders, Alkwin; Sun, Xiao-Feng; Willen, Roger; Graf, Wilhelm; Nygren, Peter; Glimelius, Bengt; Zhang, Zhi-Yong; Mahteme, Haile^*

来源：Anticancer Research, 2012, 32(4): 1443-1448.

• Pseudomyxoma peritonei
• histopathology
• PINCH
• protein expression
• cytokeratin 7
• Ki-67

Aim: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP. Materials and Methods: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables. Results: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04). Conclusion: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.

• 出版日期2012-4
• 单位唐山市工人医院