Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons

作者：Liu, Dan dan; Yang, Qian; Li, Sheng tian^*

来源：Brain Research Bulletin, 2013, 93: 10-16.

DOI：10.1016/j.brainresbull.2012.12.003

• Extrasynaptic
• NMDA receptor
• Long-term depression
• Theta burst
• MK-801
• Hippocampus

In the adult rat hippocampus, activation of N-methyl-D-aspartate receptors (NMDARs) is required for the induction of certain forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Several studies have indicated the opposing role of synaptic NMDARS (S-NMDARs) versus extrasynaptic NMDARs (ES-NMDARs) in CREB-dependent gene regulation and neuronal survival/death. The contribution of ES-NMDARs in synaptic plasticity, however, remains unclear. Here we investigated the contribution of ES-NMDARs on LTD induction in CA1 neurons of rat hippocampal slices. ES-NMDARs were selectively activated by theta burst stimulation (TBS) after selective blockade of S-NMDARs with pairing of 5 Hz stimulation and MK-801, an irreversible use-dependent antagonist of NMDARs. Application of TBS in naive slices evoked a transient potentiation. In contrast, the activation of ES-NMDARs evoked a robust LTD. These results suggest the involvement of ES-NMDARs in LTD induction.

• 出版日期2013-4
• 单位上海交通大学