ANTI-HYPERTENSIVE DRUGS HAVE DIFFERENT EFFECTS ON VENTRICULAR HYPERTROPHY REGRESSION

作者：Ferreira Filho Celso; de Abreu Luiz Carlos; Valenti Vitor E; Ferreira Marcelo; Meneghini Adriano; Silveira Jose Alexandre; Perez Riera Andres R; Colombari Eduardo; Murad Neif; Santos Silva Paulo Roberto; Henrique Pereira da Silva Lovian Jose; Marques Vanderlei Luiz Carlos; Carvalho Tatiana D; Ferreira Celso^*

来源：Clinics, 2010, 65(7): 723-728.

DOI：10.1590/S1807-59322010000700012

• Hypertrophy
• Cardiomyopathy
• Hypertrophic
• Left ventricle hypertension
• Cardiology

OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature.
METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy.
RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Cal(++) channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type I (All) receptor antagonist) produced better results than atenolol (selective 1 receptor antagonist) with respect to LVH regression.
CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.

• 出版日期2010-7