Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson's disease

作者：Tan, Ting; Song, Zhi; Yuan, Lamei; Xiong, Wei; Deng, Xiong; Ni, Bin; Chen, Yong^*; Deng, Hao^*

来源：Neuroscience Letters, 2016, 612: 189-192.

DOI：10.1016/j.neulet.2015.12.029

• Sporadic Parkinson's disease
• TREM2 gene
• rs75932628
• rs2234253
• Genetic analysis
• Chinese Han

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease and is characterized by the degeneration of dopaminergic neurons in substantia nigra. Recently, rs75932628 (p.R47H) of the triggering receptor expressed on myeloid cells 2 gene (TREM2) was identified to be associated with PD in American, Spanish, Irish, and Polish population. To explore whether TREM2 variants are related to susceptibility of sporadic PD in Chinese Han population, we designed a case control comparison study and studied two variants rs75932628 (p.R47H) and rs2234253 (p.T96K) of the TREM2 gene in 512 Chinese Han patients with sporadic PD and 512 age, gender and ethnicity matched normal controls from Mainland China. No variant for either rs75932628 or rs2234253 was found in both PD and control cohorts. Our data suggest that neither variant rs75932628 nor rs2234253 be a major susceptibility factor of sporadic PD in Chinese Han population from Mainland China.

• 出版日期2016-1-26
• 单位中南大学