An expedient ultrasonic assisted one-pot four component synthesis of novel ferrocene grafted pyrrolidine heterocycles via [3+2]-cycloaddition of azomethine ylides

作者：Babu A R Suresh; Gavaskar D; Raghunathan R^*

来源：Journal of Organometallic Chemistry, 2013, 745: 409-416.

DOI：10.1016/j.jorganchem.2013.08.014

• Ultrasound irradiation
• Multicomponent reaction (MCR)
• Ferrocene
• Azomethine ylide
• Cycloaddition
• Pyrrolidine

An expedient one-pot four component ultrasonic assisted synthesis of novel ferrocene grafted spiro-pyrrolidine heterocycles via [3 + 2]-cycloaddition of azomethine ylides is described. The protocol provides a mild reaction conditions, high yield of product in short reaction time, high regioselectivity, operational simplicity and applicable to a wide variety of ferrocene derived dipolarophiles for the efficient synthesis of ferrocene appended heterocycles. The structures of cycloadducts were confirmed by spectroscopic analysis. X-ray analysis of the products adds conclusive support to the proposed structure.

• 出版日期2013-11-15