Understanding the yeast proteome: a bioinformatics perspective

作者：Grijoriev A^*

来源：Expert Review of Proteomics, 2004, 1(2): 193-205.

• bioinformatics
• complex
• interaction
• network
• proteome
• yeast

Rapid development of genomic and proteomic methodologies has provided a wealth of data for deciphering the blomolecular circuitry of a living cell. The main areas of computational research of proteomes outlined in this review are: understanding the system, Its features and parameters to help plan the experiments; data Integration, to help produce more reliable data sets; visualization and other forms of data representation to simplify Interpretation; modeling of the functional regulation; and systems biology. With false-positive rates reaching 50% even in the more reliable data sets, handling the experimental error remains one of the most challenging tasks. Integrative approaches, Incorporating results of various genome- and proteome-wide experiments, allow for minimizing the error and bring with them significant predictive power.

• 出版日期2004-8