Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice

作者：Chen, Cong; Jie, Xu; Ou, Yangjie; Cao, Yini; Xu, Lu; Wang, Yunxia; Qi, Rong^*

来源：Nanomedicine, 2017, 12(15): 1791-1800.

DOI：10.2217/nnm-2017-0119

• nanoliposome
• naringenin
• nonalcoholic fatty liver disease

Aim: To prepare naringenin nanoliposome (NRG-Nanolipo) and investigate its inhibitory effects on nonalcoholic fatty liver disease (NAFLD). Materials & methods: NRG-Nanolipo was prepared by thin-film rehydration method. Its characterizations and effects on NAFLD in mice induced by methionine choline deficient diet were investigated. Results: NRG-Nanolipo had high-drug loading percentage and showed a sustained release profile. The nanoliposome formulation significantly increased oral absorption of naringenin (NRG). NRG-Nanolipo showed comparable inhibitory effects as NRG crude drug at a dose fourfold lower than the crude drug on NAFLD. Conclusion: It is the first study to report the inhibitory effects of NRG on NAFLD, and the NRG-Nanolipo significantly improved oral absorption of NRG, thus improved liver protective effects of NRG on NAFLD.

• 出版日期2017-8
• 单位北京大学; 重庆大学