Alkoxylation Followed by Iodination of Oxindole with Alcohols Mediated by Hypervalent Iodine Reagent in the Presence of Iodine

作者：Kotagiri, Rajendraprasad^*; Adepu, Ramesh

来源：European Journal of Organic Chemistry, 2018, 2018(33): 4556-4564.

DOI：10.1002/ejoc.201800723

• Iodine-mediated reactions
• Hypevalent Iodine
• Alcohols
• Oxindoles
• Metal-free
• Iodine

Oxidative coupling of oxindole with alcohols followed by in situ iodination by using a PhI(OCOCF3)(2)/I-2 system afforded 5-iodo-3-monoalkoxy and 5-iodo-3,3-di alkoxyoxindole in moderate to good yields. This method provides a new and transition metal-free synthesis of iodoalkoxy-substituted oxindoles in one pot from readily available oxindole under mild conditions.

• 出版日期2018-9-9
• 单位暨南大学