A correlation study between maximum standardized uptake values and pathology and clinical staging in nonsmall cell lung cancer

作者：Lu Peiou; Yu Lijuan^*; Li Yingci; Sun Yajuan

来源：Nuclear Medicine Communications, 2010, 31(7): 646-651.

DOI：10.1097/MNM.0b013e328339bddb

• adenocarcinoma
• bronchioloalveolar carcinoma
• deoxyglucose
• position emission tomography
• squamous cell carcinoma

Objective To investigate the relationship between maximum standardized uptake value and pathological type, degree of differentiation, tumor size, and clinical staging of nonsmall cell lung cancer (NSCLC).
Methods This study included 135 cases with pathologically proven NSCLC. Correlations between maximum standardized uptake value (SUV(max)) and pathological type, degree of differentiation, tumor size, and clinical staging were analyzed.
Results There was a significant correlation between the SUV(max) of NSCLC and the pathological type (r=0.391, P=0.000); the SUV(max) of squamous cell carcinoma (SCC) was higher than that of adenocarcinoma (AC) (P = 0.000), and the SUV(max) of AC was higher than that of bronchioloalveolar carcinoma (P = 0.004). There was a positive correlation between the SUV(max) of AC and the degree of differentiation (r = 0.222, P = 0.044); SUV(max) was lower in well-differentiated ACs than in moderately or poorly differentiated ACs (P = 0.034 and 0.022 respectively); however, there was no statistical difference between the moderately differentiated and poorly differentiated groups (P = 1.000). There was no correlation between the SUV(max) of SCC and the degree of differentiation (r = -0.304, P = 0.054). A positive correlation was found between the SUV(max) of NSCLC and tumor size (r = 0.569, P = 0.000). The SUV(max) of AC had a positive correlation with clinical staging (r = 0.298, P = 0.006); SUV(max) was lower in stage I than in stages II, III, and IV (P = 0.047, 0.038 and 0.015, respectively); however, the SUV(max) in stages II, III, and IV were not different (P = 0.708, 0.570 and 0.528, respectively). There was no correlation between the SUV(max) of SCC and clinical staging (r = 0.066, P = 0.680).
Conclusion There was a correlation between the SUV(max) of NSCLC and the pathological type and tumor size. A positive correlation was found between the SUV(max) of AC and the degree of differentiation and clinical staging. There were no correlations between the SUV(max) of SCC and the degree of differentiation or clinical staging.

• 出版日期2010-7
• 单位哈尔滨医科大学