Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

作者：Scheuer K H^*; Svenstrup K; Jennum P; Rogvi Hansen B a; Werdelin L; Fenger K; Nielsen J E

来源：European Journal of Neurology, 2007, 14(6): 663-666.

DOI：10.1111/j.1468-1331.2007.01812.x

• gabapentin
• hereditary spastic paraplegia
• motor cortical excitability
• P-TMS
• spasticity
• SPG4

Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

• 出版日期2007-6
• 单位河北医科大学