Complete Sequencing of Plasmids Containing bla(OXA-163) and bla(OXA-48) in Escherichia coli Sequence Type 131

作者：Stoesser Nicole; Sheppard Anna E; Peirano Gisele; Sebra Robert; Lynch Tarah; Anson Luke; Kasarskis Andrew; Motyl Mary R; Crook Derrick W; Pitout Johann D

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(11): 6948-6951.

DOI：10.1128/AAC.01130-16

OXA-48-like enzymes have emerged as important extended-spectrum beta -lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla(OXA-163) plasmid and of two other bla(OXA-48) plasmids in this lineage. bla(OXA-163) was located on a 71-kb IncN plasmid with other resistance genes. bla(OXA-48) was present on IncL/M plasmids, genetically similar to other bla(OXA-48) plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla(OXA-48)-like genes on epidemic plasmids in ST131 is of concern.

• 出版日期2016-11