Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species

作者：Loizzo Monica R^*; Saab Antoine M; Tundis Rosa; Statti Giancarlo A; Menichini Francesco; Lampronti Ilaria; Gambari Roberto; Cinatl Jindrich; Doerr Hans Wilhelm

来源：Chemistry and Biodiversity, 2008, 5(3): 461-470.

DOI：10.1002/cbdv.200890045

The chemical composition of the essential oils of Laurus nobilis, Juniperus oxycedrus ssp. oxycedrus, Thuja orientalis, Cupressus sempervirens ssp. pyramidalis, Pistacia palaestina, Salvia officinalis, and Satureja thymbra was determined by GC/MS analysis. Essential oils have been evaluated for their inhibitory activity against SARS-CoV and HSV-1 replication in vitro by visually scoring of the virus-induced cytopathogenic effect post-infection. L. nobilis oil exerted an interesting activity against SARS-CoV with an IC50 value of 120 mu g/ml and a selectivity index (SI) of 4.16. This oil was characterized by the presence of beta-ocimene, 1,8-cineole, alpha-pinene, and beta-pinene as the main constituents. J. oxycedrus ssp. oxycedrus oil, in which alpha-pinene and beta-myrcene were the major constituents, revealed antiviral activity against HSV-1 with an IC50 value of 200 mu g/ml and a SI of 5.

• 出版日期2008
• 单位河北医科大学