Altered balance of functional brain networks in Schizophrenia

作者：Woodward Todd S^*; Leong KaWai; Sanford Nicole; Tipper Christine M; Lavigne Katie M

来源：Psychiatry Research: Neuroimaging , 2016, 248: 94-104.

DOI：10.1016/j.pscychresns.2016.01.003

• Functional magnetic resonance imaging
• Functional connectivity
• Stroop stimuli
• Task switching

Activity in dorsal attention (DAN) and frontoparietal (FPN) functional brain networks is linked to allocation of attention to external stimuli, and activity in the default-mode network (DMN) is linked to allocation of attention to internal representations. Tasks requiring attention to external stimuli shift activity to the DAN/FPN and away from the DMN, and optimal task performance depends on balancing DAN/FPN against DMN activity. The current functional magnetic resonance imaging (fMRI) study assessed the balance of DAN/FPN and DMN activity in 13 schizophrenia patients and 13 healthy controls while they were engaged in a task switching Stroop paradigm which demanded internally directed attention to task instructions. The typical pattern of reciprocity between the DAN/FPN and DMN was observed for healthy controls but not for patients, suggesting a reduction in the internally focussed thought important for maintenance of instructions and strategies in schizophrenia. The observed alteration in the balance between DAN/FPN and DMN in patients may reflect a general mechanism underlying multiple forms of cognitive impairment in schizophrenia, including global processing deficits such as cognitive inefficiency and impaired context processing.

• 出版日期2016-2-28