科研之友
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摘要
Peritoneal dialysis is an important method of renal replacement therapy for patients with end-stage renal disease. The rate of fluid removal from the patient, i.e. ultrafiltration, depends on the concentration of the osmotic agent (most often glucose) in the dialysate. According to the, three-pore model" of peritoneal transport, ultrasmall pores (aquaporins) are water-specific, and during a hypertonic dwell they can contribute up to 50% of the total ultrafiltration. Experimental studies on animal models have demonstrated the role of aquaporin-1 in water transport and its regulation by hyperosmolality, and have proved the influence of corticosteroid administration on aquaporin-1 function. Experimental studies have also demonstrated other aquaporin-1 properties, such as its role in cell migration, wound healing and tumor growth, and suggested that aquaporin-1 may play a role in leukocyte recruitment during peritonitis. Future studies in peritoneal dialysis patients should assess the influence of aquaporin-1 gene polymorphism on the variability of free water transport and the course of peritonitis (Adv Clin Exp Med 2011, 20, 2, 217-220).
- 出版日期2011
