An approach to synthesis of (Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent (bis-(trichloromethyl) carbonate/DMF)

作者：Weng Yi Yi; Li Jian Jun; Su Wei Ke^*

来源：Chinese Chemical Letters, 2011, 22(12): 1395-1398.

DOI：10.1016/j.cclet.2011.07.006

• Ring-opening
• Halogenation
• Vilsmeier reagent
• Bis-(trichloromethyl)carbonate
• (Z)-2-Chloro-1,3-diaryl-2-enones

A series of (Z)-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1, 3-diarylpropan-1-ones with Vilsmeier reagent, which was derived from bis(trichloromethyl) carbonate (BTC, triphosgene) and DMF. A possible mechanism was also proposed, where sequential ring-opening, halogenation and elimination reactions were involved.

• 出版日期2011-12
• 单位浙江工业大学