Phytoestrogens and bone health

作者：Lagari Violet S; Levis Silvina

来源：Current Opinion in Endocrinology Diabetes and Obesity, 2010, 17(6): 546-553.

DOI：10.1097/MED.0b013e32833f4867

• bone
• menopause
• osteoporosis
• phytoestrogens
• soy isoflavones

Purpose of review
The present review summarizes the results of epidemiological studies and clinical trials assessing the skeletal effects of soy foods and soy dietary supplements.
Recent findings
Results from epidemiological studies suggest a beneficial skeletal effect in Asian women consuming typical Asian diets, but clinical trials are conflictive regarding the effects of phytoestrogens on bone mineral density and bone turnover markers in premenopausal and postmenopausal women. Much of the controversy lies in differences in study design, reporting of results, participants' age and menopausal status, and type and dose of phytoestrogen used.
Summary
Although western women will likely continue to incorporate soy foods and soy supplements into their diets with the increased availability of these products, published data are inconsistent and do not support soy's protective effect against bone loss. This conflicting evidence should be taken into account when considering using isoflavones in the prevention of bone loss and consequently fractures.

• 出版日期2010-12